Parasitology
Current Projects | Reports | Posters | Anthelmintic Resistance Papers
The research projects within the Parasitology Division focus on two main areas, immunopathogenesis and parasite control. Recently individual enzyme components of the Haemonchus antigen complexes have been expressed in eukaryotic systems and one has shown modest protection against challenge infection. Expressed sequence tag analysis of components of the sheep scab mite has identified up to 7 allergens which may be associated with mite pathogenesis. A robust model of Neosporosis has been established in cattle and this will be used to compare the rates of vertical transmission of N. caninum in cattle exposed to infection during different periods of gestation. An in depth investigation into the prevalence of nematodes that are resistant to anthelmintics has been completed on sheep farms in Scotland. Overall about 60 per cent of farms harboured nematodes resistant to benzimidazoles and in some regions this was as high as 90 per cent.
Current Projects
- Protective immunity against
Neospora caninum
Principal contact: Dr Lee Innes (SEERAD core funded project) - Characterisation studies on
anthelmintic resistance in Teladorsagia
Principal contact: Dr Frank Jackson (SEERAD core funded project) - Non-therapeutic approaches
to control of parasitic gastroenteritis in small ruminants
Principal contact: Dr Frank Jackson (SEERAD core funded project) - Host reponses to
sheep scab
Principal contacts: Dr John Huntley (SEERAD core funded project) - Muscosal immunity to
gastrointestinal nematode parasites
Principal contact: Dr John Huntley (SEERAD core funded project) - Intestinal cell membrane
proteins from non blood-feeding parasitic nematodes as protective
antigens for ruminants
Principal contacts: Dr David Smith (SEERAD core funded project) - Toward a vaccine
for Haemonchus contortus, an important nematode parasite
of sheep
Principal contact: Dr David Smith (SEERAD core funded project) - Host-parasite interactions
in Teladorsagia circumcincta infections in sheep
Principal contact: Dr Jacqui Matthews / Dr David Knox (SEERAD core funded project) - Adaptation of Caenorhabditis
elegans technology to identification and expression of parasite
target genes
Principal contact: Dr David Knox (SEERAD flexible funded project) - Development of molecular
approaches to identify Ivermectin resistance in Teladorsagia
Principal contacts: Dr Frank Jackson / Dr Philip Skuce (SEERAD flexible funded project) - The molecular basis of
anthelmintic resistance in parasitic nematodes and the development
of rapid detection systems
Principal contact: Dr Philip Skuce (SEERAD collaborative flexible funded project) - Identification of vaccine
candidates in larval excretory/secretory products of Teladorsagia
circumcincta
Principal contact: Dr Jacqui Matthews (SEERAD collaborative flexible funded project) - Identification of candidate
protective antigens for vaccination against the bovine lungworm
Dictyocaulus
viviparus
Principal contact: Dr Jacqui Matthews (BBSRC collaborative funded project) - The application of Haemonchus
contortus in sheep to the development of hookworm vaccines in
dogs and humans
Principal contact: Dr David Knox (Albert Sabin Vaccine Institute funded project) - Adaptation of Caenorhabditis
elegans technology to express and identify parasite target genes
Principal contact: Dr David Knox (Marie Curie Intra European Fellowship funded project) - Immunological approaches
to the control of sheep scab
Principal contacts: Dr David Smith / Dr John Huntley (Defra funded project) - Plants and their extracts and
other natural alternatives to antimicrobials in feeds
Principal contacts: Dr Frank Jackson (EU funded project) - Integration of functional
genomics and immunology and their application to infectious diseases
in ruminants
Principal contact: Dr David Smith (Uni of Edinburgh, Uni of Glasgow, Institute of Animal Health, MRI, Roslin and VLA funded project)
Reports
- "Sheep Scab: towards vaccination" (written by Dr John Huntley)
- "Avermectin resistance survey emphasises need for best practice" (written by Dr Frank Jackson and David Bartley)
- "Neosporosis: looking at the host parasite relationship" (written by Dr Lee Innes)
- "Neospora caninum: A fascinating relationship between parasite and host" (written by Dr Lee Innes)
- "Control of gastro-intestinal nematode parasites of ruminants with vaccines" (written by Dr David Smith)
- "Strategic worm control" (written by Dr Frank Jackson)
- "Eosinophils and Sheep Scab" (written by Dr Doug Jones and Dr John Huntley)
- "Detection of Cryptosporidium arvum in shellfish" (written by Dr Steve Wright)
- "Millennial Anthelmintic Resistance Survey" (written by Dr Frank Jackson)
Posters
- List of posters has been moved to the Virtual Poster Room
Anthelmintic Resistance Papers
- Novel solutions for the sustainable control of nematodes in ruminants (PARASOL)
Veterinary Parasitology, In Press, Corrected Proof, Available online 4 May 2009
Jozef Vercruysse, Frank Jackson, Brown Besier, Bill Pomroy - The role of targeted selective treatments in the development of refugia-based approaches to the control of gastrointestinal nematodes of small ruminants
Veterinary Parasitology, In Press, Corrected Proof, Available online 15 April 2009
F. Kenyon, A.W. Greer, G.C. Coles, G. Cringoli, E. Papadopoulos, J. Cabaret, B. Berrag, M. Varady, J.A. Van Wyk, E. Thomas, J. Vercruysse, F. Jackson - Evaluation of targeted selective treatments in sheep in Italy: Effects on faecal worm egg count and milk production in four case studies
Veterinary Parasitology, In Press, Corrected Proof, Available online 15 April 2009
G. Cringoli, L. Rinaldi, V. Veneziano, L. Mezzino, J. Vercruysse, F. Jackson - Development and field evaluation of a decision support model for anthelmintic treatments as part of a targeted selective treatment (TST) regime in lambs
Veterinary Parasitology, In Press, Corrected Proof, Available online 15 April 2009
A.W. Greer, F. Kenyon, D.J. Bartley, E.B. Jackson, Y. Gordon, A.A. Donnan, D.W. McBean, F. Jackson - Sheep helminth parasitic disease in south eastern Scotland arising as a possible consequence of climate change
Veterinary Parasitology, In Press, Corrected Proof, Available online 26 March 2009
F. Kenyon, N.D. Sargison, P.J. Skuce, F. Jackson - P-glycoprotein interfering agents potentiate ivermectin
susceptibility in ivermectin sensitive and resistant isolates of Teladorsagia circumcincta and Haemonchus contortus.
Parasitology, volume 136, Pages 1081-1088. D. J. Bartley, H. Mcallister, Y. Bartley, J. Dupuy, C. Menez, M. Alvinerie, F. Jackson and A. Lespine - Anthelmintic resistance in Swedish sheep flocks based on a comparison of the results from the faecal egg count reduction test and resistant allele frequencies of the β-tubulin gene
Veterinary Parasitology, Volume 161, Issues 1-2, 6 April 2009, Pages 60-68
J. Höglund, K. Gustafsson, B.-L. Ljungström, A. Engström, A. Donnan, P. Skuce - Effects of strategic anthelmintic treatments on the milk production of dairy sheep naturally infected by gastrointestinal strongyles
Veterinary Parasitology, Volume 156, Issues 3-4, 1 October 2008, Pages 340-345
G. Cringoli, V. Veneziano, F. Jackson, J. Vercruysse, A.W. Greer, V. Fedele, L. Mezzino, L. Rinaldi - Microsatellite analysis reveals marked genetic differentiation between Haemonchus contortus laboratory isolates and provides a rapid system of genetic fingerprinting
International Journal for Parasitology, Volume 38, Issue 1, January 2008, Pages 111-122
E. Redman, E. Packard, V. Grillo, J. Smith, F. Jackson, J. S. Gilleard - Attempts to detect synergy between vaccination and anthelmintic against a drug resistant isolate of Haemonchus contortus
Veterinary Parasitology, Volume 148, Issues 3-4, 30 September 2007, Pages 356-359
W.D. Smith - Haemonchosis and teladorsagiosis in a Scottish sheep flock putatively associated with the overwintering of hypobiotic fourth stage larvae
Veterinary Parasitology, Volume 147, Issues 3-4, 20 July 2007, Pages 326-331
N.D. Sargison, D.J. Wilson, D.J. Bartley, C.D. Penny, F. Jackson - Observations on the emergence of multiple anthelmintic resistance in sheep flocks in the south-east of Scotland
Veterinary Parasitology, Volume 145, Issues 1-2, 10 April 2007, Pages 65-76
N.D. Sargison, F. Jackson, D.J. Bartley, D.J. Wilson, L.J. Stenhouse, C.D. Penny - Detection and measurement of benzimidazole resistance alleles in Haemonchus contortus using real-time PCR with locked nucleic acid Taqman probes
Veterinary Parasitology, Volume 144, Issues 3-4, 31 March 2007, Pages 304-312
T. K. Walsh, A. A. Donnan, F. Jackson, P. Skuce, A. J. Wolstenholme - Characterisation of Teladorsagia circumcincta microsatellites and their development as population genetic markers
Molecular and Biochemical Parasitology, Volume 148, Issue 2, August 2006, Pages 181-189
V. Grillo, F. Jackson, J. S. Gilleard - Alternative approaches to control—Quo vadit?
Veterinary Parasitology, Volume 139, Issue 4, 31 July 2006, Pages 371-384
F. Jackson, J. Miller - A small scale survey of ivermectin resistance in sheep nematodes using the faecal egg count reduction test on samples collected from Scottish sheep
Veterinary Parasitology, Volume 137, Issues 1-2, 15 April 2006, Pages 112-118
D.J. Bartley, A.A. Donnan, E. Jackson, N. Sargison, G.B.B. Mitchell, F. Jackson - The detection of anthelmintic resistance in nematodes of veterinary importance
Veterinary Parasitology, Volume 136, Issues 3-4, 31 March 2006, Pages 167-185
G.C. Coles, F. Jackson, W.E. Pomroy, R.K. Prichard, G. von Samson-Himmelstjerna, A. Silvestre, M.A. Taylor, J. Vercruysse - Further characterisation of a triple resistant field isolate of Teladorsagia from a Scottish lowland sheep farm
Veterinary Parasitology, Volume 134, Issues 3-4, 10 December 2005, Pages 261-266
D.J. Bartley, E. Jackson, N. Sargison, F. Jackson - The larval feeding inhibition assay for the diagnosis of nematode anthelmintic resistance
Experimental Parasitology, Volume 110, Issue 1, May 2005, Pages 56-61
M.A. Álvarez-Sánchez, J. Pérez García, D. Bartley, F. Jackson, F.A. Rojo-Vázquez - Veterinary anthelmintics: old and new
Trends in Parasitology, Volume 20, Issue 10, October 2004, Pages 456-461
Q. A. McKellar, F. Jackson - Studies using Teladorsagia circumcincta in an in vitro direct challenge method using abomasal tissue explants
Veterinary Parasitology, Volume 124, Issues 1-2,
20 September 2004, Pages 73-89
F. Jackson, A.W. Greer, J. Huntley, R.W. McAnulty, D.J. Bartley, A. Stanley, L. Stenhouse, M. Stankiewicz, A.R. Sykes - Characterisation of two triple resistant field isolates of Teladorsagia from Scottish lowland sheep farms
Veterinary Parasitology, Volume 123, Issues 3-4, 2 September 2004, Pages 189-199
D.J. Bartley, F. Jackson, E. Jackson, N. Sargison - A survey of anthelmintic resistant nematode parasites in Scottish sheep flocks
Veterinary Parasitology, Volume 117, Issues 1-2, 3 November 2003, Pages 61-71
D. J. Bartley, E. Jackson, K. Johnston, R. L. Coop, G. B. B. Mitchell, J. Sales, F. Jackson - Comparative field evaluation of divided-dosing and reduced feed intake upon treatment efficacy against resistant isolates of Teladorsagia circumcincta in sheep and goats
Research in Veterinary Science, Volume 64, Issue 2,
March-April 1998, Pages 101-104
M. Barrett, F. Jackson, M. Patterson, E. Jackson, Q. A. McKellar - Anthelmintic resistance—The state of play
British Veterinary Journal, Volume 149, Issue 2, 1993,
Pages 123-138
F. Jackson,M. Monteiro, S. W. Wanyangu, D. P. Kariuki, R. Bain, F. Jackson, Q. A. McKellar - Pharmaceutical quality of anthelmintics sold in Kenya
Veterinary Record, Volume 142,Issue 15, April 1998,
Pages 396 - 398
F Jackson, E Jackson, S Little, RL Coop, AJ Russel - Prevalence of anthelmintic-resistant nematodes in fibre-producing goats in Scotland
Veterinary Record, Volume 131, Issue 13, September 1992, Pages 282 - 285.
F Jackson, RL Coop, E Jackson, S Little, AJ Russel - Anthelmintic resistant nematodes in goats (letter; not available online)
Veterinary Record, Volume 129, July 1991,Issue 2,
Pages 39 - 40.
F Jackson, RL Coop, E Jackson, EW Scott, AJ Russel - Multiple anthelmintic resistant nematodes in goats (letter; not available online)
Veterinary Record, Volume 130, Issue 10, March 1992,
Pages 210 - 211
N. D. Sargison, P. R. Scott, F. Jackson - Teladorsagiosis in young lambs and extended postparturient susceptibility in moxidectin-treated ewes grazing heavily contaminated pastures
Veterinary Record, Volume 151,Issue 12, September 2002, Pages 353 - 355
GB Mitchell, F Jackson, RL Coop - Anthelmintic resistance in Scotland (letter; not available online)
Veterinary Record, Volume 129, Issue 3, July 1991, Page 58
ND Sargison, F Jackson, DJ Bartley, AC Moir - Failure of moxidectin to control benzimidazole-, levamisole- and ivermectin-resistant Teladorsagia circumcinda in a sheep flock
Veterinary Record, Volume 156, Issue 4, January 2005,
Pages 105 – 109
ND Sargison, F.Jackson, DJ Bartley, AC Moir